Technology Process of (+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate
There total 8 articles about (+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diisibutylaluminium hydride (DIBALH) / toluene; hexane / 1 h / -78 °C
2: 64.1 percent / tetrahydrofuran / 27.5 h / Ambient temperature
3: hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 17 h / 80 °C
4: ethyl acetate / Ambient temperature
5: 1.) 40percent peracetic acid, 2.) pyridine / 1.) 15 min, room temp., 2.) 55 deg C, 1.2h
With
pyridine; peracetic acid; N,N,N,N,N,N-hexamethylphosphoric triamide; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; ethyl acetate; toluene;
DOI:10.1021/jo00319a031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 64.1 percent / tetrahydrofuran / 27.5 h / Ambient temperature
2: hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 17 h / 80 °C
3: ethyl acetate / Ambient temperature
4: 1.) 40percent peracetic acid, 2.) pyridine / 1.) 15 min, room temp., 2.) 55 deg C, 1.2h
With
pyridine; peracetic acid; N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo00319a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 17 h / 80 °C
2: ethyl acetate / Ambient temperature
3: 1.) 40percent peracetic acid, 2.) pyridine / 1.) 15 min, room temp., 2.) 55 deg C, 1.2h
With
pyridine; peracetic acid; N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo00319a031
