(+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate

Base Information

Chemical Name:(+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate
CAS No.:76248-72-1
Molecular Formula:C₁₄H₂₂O₃
Molecular Weight:238.327
Hs Code.:

Synonyms:(+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate

Suppliers and Price of (+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate

There total 8 articles about (+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76215-55-9
trans-hexahydro-7a-methyl-2(3H)-benzofuranone

: 76248-72-1
(+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate

Guidance literature:: Multi-step reaction with 5 steps

1: diisibutylaluminium hydride (DIBALH) / toluene; hexane / 1 h / -78 °C

2: 64.1 percent / tetrahydrofuran / 27.5 h / Ambient temperature

3: hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 17 h / 80 °C

4: ethyl acetate / Ambient temperature

5: 1.) 40percent peracetic acid, 2.) pyridine / 1.) 15 min, room temp., 2.) 55 deg C, 1.2h

With pyridine; peracetic acid; N,N,N,N,N,N-hexamethylphosphoric triamide; diisobutylaluminium hydride; In tetrahydrofuran; hexane; ethyl acetate; toluene;
DOI:10.1021/jo00319a031

Reference yield:

: 70302-33-9
(+/-)-trans-(2-hydroxy-2-methylcyclohexane)acetaldehyde

: 76248-72-1
(+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 64.1 percent / tetrahydrofuran / 27.5 h / Ambient temperature

2: hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 17 h / 80 °C

3: ethyl acetate / Ambient temperature

4: 1.) 40percent peracetic acid, 2.) pyridine / 1.) 15 min, room temp., 2.) 55 deg C, 1.2h

With pyridine; peracetic acid; N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo00319a031

Reference yield:

: 70302-24-8,76248-73-2
(+/-)-<1α(E),2β>-3-<2-(2-hydroxy-2-methylcyclohexyl)-ethylidene>dihydro-2(3H)-furanone

: 76248-72-1
(+/-)-<1α(E),2β>-methyl 2-ethenyl-4-(2-hydroxy-2-methylcyclohexyl)-2-butenoate

Guidance literature:: Multi-step reaction with 3 steps

1: hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 17 h / 80 °C

2: ethyl acetate / Ambient temperature

3: 1.) 40percent peracetic acid, 2.) pyridine / 1.) 15 min, room temp., 2.) 55 deg C, 1.2h

With pyridine; peracetic acid; N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo00319a031