(R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid
• CAS No.: 817624-47-8
• Molecular Formula: C₃₉H₄₈N₄O₈
• Molecular Weight: 700.832

Synonyms:(R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Chemical Property of (R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Chemical Property:

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Technology Process of (R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

There total 1 articles about (R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid methyl ester → (R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid (817624-47-8)

Guidance literature:

With lithium hydroxide; In methanol; water;

DOI:10.1016/j.tetlet.2004.10.024

Reference yield:

(R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid (817624-47-8) → Acetic acid (5S,9S,14aR)-5,9-dibenzyl-4,7,11,14-tetraoxo-tetradecahydro-3a,6,10,13-tetraaza-cyclopentacyclotridecen-12-yl ester

Guidance literature:

Multi-step reaction with 4 steps

1: CF₃COOH / tetrahydrofuran

2: BOP; DMAP

3: 100 percent / H₂; HCl / Pd/C / methanol

4: 61 percent / ethyl acetate

With hydrogenchloride; dmap; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1016/j.tetlet.2004.10.024

Reference yield:

(R)-1-{(S)-2-[(S)-3-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-phenyl-butyrylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid (817624-47-8) → (5S,9S,12S,14aR)-5,9-Dibenzyl-12-hydroxymethyl-decahydro-3a,6,10,13-tetraaza-cyclopentacyclotridecene-4,7,11,14-tetraone

Guidance literature:

Multi-step reaction with 3 steps

1: CF₃COOH / tetrahydrofuran

2: BOP; DMAP

3: 100 percent / H₂; HCl / Pd/C / methanol

With hydrogenchloride; dmap; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2004.10.024

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