3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde

Base Information

• Chemical Name: 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde
• CAS No.: 81541-41-5
• Molecular Formula: C₁₅H₉ClN₂O₂
• Molecular Weight: 284.702
• Mol file: 81541-41-5.mol

Synonyms:3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde

Chemical Property of 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde

There total 6 articles about 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

R,S-N-(<3-<4-Chlorphenyl>-3,4-dihydro-4-oxo-2-chinazolinyl>-hydroxymethyl)acetamid (81541-40-4) → 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde (81541-41-5)

Guidance literature:

at 200 ℃; under 0.05 Torr;

DOI:10.1007/BF00799022

Reference yield: 79.0%

3-(4-chlorophenyl)-2-methyl-3H-quinazolin-4-one (1788-93-8) → 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde (81541-41-5)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 70 - 80 ℃; for 3h;

Reference yield:

R,S-Essigsaeure(acetamido-<3-<4-chlorphenyl>-3,4-dihydro-4-oxo-2-chinazolinyl>-methyl)ester (81552-42-3) → 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde (81541-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) H₂O / acetic acid / Heating; 1.) 5 min, 2.) 5 min

2: 90 percent / 200 °C / 0.05 Torr

With water; In acetic acid;

DOI:10.1007/BF00799022

upstream raw materials:

3-(4-chlorophenyl)-2-methyl-3H-quinazolin-4-one

R,S-N-(<3-<4-Chlorphenyl>-3,4-dihydro-4-oxo-2-chinazolinyl>-hydroxymethyl)acetamid

R,S-Essigsaeure(acetamido-<3-<4-chlorphenyl>-3,4-dihydro-4-oxo-2-chinazolinyl>-methyl)ester

2-Azidomethyl-3-(4-chlorphenyl)-3,4-dihydro-4-chinazolinon

Downstream raw materials:

C₁₉H₁₆ClN₅OS

C₂₂H₁₅Cl₂N₅OS

C₁₆H₁₂ClN₅OS

C₁₇H₁₄ClN₅OS