ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate

Base Information

• Chemical Name: ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate
• CAS No.: 485819-20-3
• Molecular Formula: C₂₁H₁₇Cl₂NO₄
• Molecular Weight: 418.276

Synonyms:ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate

Chemical Property of ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate

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Technology Process of ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate

There total 2 articles about ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 2-cyanoacetate (105-56-6) + 4-chlorobenzoylmethyl bromide (536-38-9) → ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate (485819-20-3)

Guidance literature:

With potassium carbonate; In butanone; at 5 - 10 ℃;

Reference yield: 70.0%

ethyl 2-cyano-2-cyclohexylideneacetate (6802-76-2) + 4-chlorobenzoylmethyl bromide (536-38-9) → ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate (485819-20-3)

Guidance literature:

With potassium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1134/S1070428015120040

Reference yield: 71.0%

ethyl 4-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-2-cyano 4-oxobutanoate (485819-20-3) → 2,6-bis(4-chlorophenyl)-4-cyano-4-ethoxycarbonyl-4H-pyran (485819-38-3)

Guidance literature:

With phosphorus pentoxide; In benzene; for 10h; Heating;

DOI:10.1002/jhet.5570390408

upstream raw materials:

ethyl 2-cyanoacetate

4-chlorobenzoylmethyl bromide

ethyl 2-cyano-2-cyclohexylideneacetate

Downstream raw materials:

2,6-bis(4-chlorophenyl)-4-cyano-4-ethoxycarbonyl-4H-pyran

2,6-bis(4-chlorophenyl)-4-cyano-4-ethoxycarbonyl-4H-thiopyran

2,6-bis(4-chlorophenyl)-4-cyano-4-ethoxycarbonyl-1,4-dihydropyridine

4-(4-chloro-phenyl)-2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-4-oxo-butyric acid

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