acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester

Base Information

• Chemical Name: acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester
• CAS No.: 889868-61-5
• Molecular Formula: C₁₃H₁₀F₃NO₃
• Molecular Weight: 285.223
• Mol file: 889868-61-5.mol

Synonyms:acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester

Chemical Property of acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester

There total 4 articles about acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

acetic anhydride (108-24-7) + 2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-ynyl)phenyl)acetamide (148564-88-9) → acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester (889868-61-5)

Guidance literature:

With pyridine; at 20 ℃; for 2h;

DOI:10.1021/ol060499n

Reference yield:

2-iodophenylamine (615-43-0) → acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester (889868-61-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₂NH; CuI; PdCl₂(PPh₃)2 / dimethylformamide / 12 h / 60 °C

2: Et₃N / tetrahydrofuran / 2 h / 20 °C

3: p-toluenesulfonic acid hydrate / acetone; H₂O / 6 h / 40 °C

4: 78 percent / pyridine / 2 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; toluene-4-sulfonic acid; diethylamine; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; 1: Sonogashira cross-coupling;

DOI:10.1021/ol060499n

Reference yield:

2,2,2-Trifluoro-N-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-acetamide (201813-43-6) → acetic acid 3-[2-(2,2,2-trifluoro-acetylamino)-phenyl]-prop-2-ynyl ester (889868-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid hydrate / acetone; H₂O / 6 h / 40 °C

2: 78 percent / pyridine / 2 h / 20 °C

With pyridine; toluene-4-sulfonic acid; In water; acetone;

DOI:10.1021/ol060499n

upstream raw materials:

acetic anhydride

2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-ynyl)phenyl)acetamide

2-iodophenylamine

2,2,2-Trifluoro-N-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-acetamide