4-benzylbenzoic acid cholesteryl ester

Base Information

• Chemical Name: 4-benzylbenzoic acid cholesteryl ester
• CAS No.: 83038-71-5
• Molecular Formula: C₄₁H₅₆O₂
• Molecular Weight: 580.894
• Mol file: 83038-71-5.mol

Synonyms:4-benzylbenzoic acid cholesteryl ester

Chemical Property of 4-benzylbenzoic acid cholesteryl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-benzylbenzoic acid cholesteryl ester

There total 9 articles about 4-benzylbenzoic acid cholesteryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-benzylsulfanyl-2,3,5,6-tetrafluoropyridine (943868-13-1) + (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta [a]phenanthren-3-yl 4-bromobenzoate → 4-benzylbenzoic acid cholesteryl ester (83038-71-5)

Guidance literature:

With manganese; NiCl₂(bathocuproine); magnesium bromide; In N,N-dimethyl acetamide; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.joc.1c02897

Reference yield: 30.0%

2-benzyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one + (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta [a]phenanthren-3-yl 4-bromobenzoate → 4-benzylbenzoic acid cholesteryl ester (83038-71-5)

Guidance literature:

With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; Ni(cod)₂*4,4'-di-tert-butyl-2,2'-bipyridine; sodium phosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Schlenk technique; Sealed tube; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03672

Reference yield:

4-Benzylbenzoic acid (620-86-0) → 4-benzylbenzoic acid cholesteryl ester (83038-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorous pentachloride

2: pyridine / benzene / 10 h / Ambient temperature

With pyridine; phosphorus pentachloride; In benzene;

DOI:10.1080/00268948208072592

upstream raw materials:

4-benzylbenzoyl chloride

4-Benzylbenzoic acid

cholesterol

4-Methylbenzophenone