3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride

Base Information

Chemical Name:3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride
CAS No.:81593-52-4
Molecular Formula:C₂₄H₃₁NO₅*ClH
Molecular Weight:449.975
Hs Code.:

Synonyms:3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride

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Chemical Property of 3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride

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Technology Process of 3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride

There total 5 articles about 3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

: 81593-66-0
3-(2-ethyl-1,2,3,4-tetrahydro-7-methoxy-1-isoquinolyl)propanol

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 81593-52-4
3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride

Guidance literature:: With triethylamine; In benzene; for 3h; Heating;
DOI:10.1248/cpb.30.180

Reference yield:

: 81593-63-7
1-(3-benzoyloxypropyl)-7-methoxyisoquinoline

: 81593-52-4
3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / 4.5 h / 100 °C

2: 92.1 percent / NaBH₄ / methanol; H₂O / 2 h / Ambient temperature

3: 92.1 percent / H₂, 10percent HCl / 25percent Pd-C / ethanol

4: 79.2 percent / triethylamine / benzene / 3 h / Heating

With hydrogenchloride; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; water; benzene;
DOI:10.1248/cpb.30.180

Reference yield:

: 2-Benzyl-7-methoxy-1,2,3,4-tetrahydro-isoquinoline-1-carbonitrile

: 81593-52-4
3,4-Dimethoxy-benzoic acid 3-(2-ethyl-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / 50percent NaH / dimethylformamide / 4.5 h

2: 96 percent / 4.5 h / 100 °C

3: 92.1 percent / NaBH₄ / methanol; H₂O / 2 h / Ambient temperature

4: 92.1 percent / H₂, 10percent HCl / 25percent Pd-C / ethanol

5: 79.2 percent / triethylamine / benzene / 3 h / Heating

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.30.180