(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide

Base Information

Chemical Name:(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide
CAS No.:1374968-97-4
Molecular Formula:C₁₇H₁₈FN₅OS
Molecular Weight:359.427
Hs Code.:

Synonyms:(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide

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Chemical Property of (R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide

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Technology Process of (R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide

There total 3 articles about (R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374968-96-3
(R)-2-(5-bromo-4-cyano-2-fluorophenylamino)-3-cyclopropylpropanamide

: 71134-43-5,52547-00-9
3-methyl-5-aminoisothiazole hydrochloride

: 1374968-97-4
(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide

Guidance literature:: With potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 120 ℃; for 36h; Inert atmosphere;

Reference yield:

: 64695-82-5
2-bromo-4,5-difluorobenzonitrile

: 1374968-97-4
(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 120 °C

2: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 36 h / 120 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 1374159-69-9
(R)-2-amino-3-cyclopropylpropanamide

: 1374968-97-4
(R)-2-(4-cyano-2-fluoro-5-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclopropylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 120 °C

2: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 36 h / 120 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; dimethyl sulfoxide;