6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine

Base Information

Chemical Name:6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine
CAS No.:357930-21-3
Molecular Formula:C₄₅H₅₈N₂O₅SSi₂
Molecular Weight:795.203
Hs Code.:

Synonyms:6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine

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Chemical Property of 6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine

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Technology Process of 6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine

There total 3 articles about 6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 67-68-5,8070-53-9
dimethyl sulfoxide

: 357930-19-9
6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-hydroxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine

: 357930-21-3
6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine

Guidance literature:: With acetic anhydride; at 20 ℃; for 36h;
DOI:10.1081/SCC-100103324

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 357930-21-3
6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 83 percent / dimethylaminppyridine / pyridine / 96 h / 20 °C

2.1: n-BuLi / tetrahydrofuran / 0.5 h / -55 °C

2.2: 75 percent / tetrahydrofuran / 2 h / -55 °C

3.1: 70 percent / Ac₂O / 36 h / 20 °C

With n-butyllithium; dimethylaminppyridine; acetic anhydride; In tetrahydrofuran; pyridine;
DOI:10.1081/SCC-100103324

Reference yield:

: 172843-10-6
1,3-bis[[tert-butyl(diphenyl)silyl]oxy]propan-2-one

: 357930-21-3
6-[2-[(1,3-bis-(tert-butyldiphenylsilyloxy)-2-methylthiomethyloxy)propyl]methyl]-2,4-dimethoxy-5-methylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -55 °C

1.2: 75 percent / tetrahydrofuran / 2 h / -55 °C

2.1: 70 percent / Ac₂O / 36 h / 20 °C

With n-butyllithium; acetic anhydride; In tetrahydrofuran;
DOI:10.1081/SCC-100103324