ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate

Base Information

Chemical Name:ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate
CAS No.:290826-63-0
Molecular Formula:C₁₈H₂₄BrClN₂O₆
Molecular Weight:479.755
Hs Code.:

Synonyms:ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate

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Chemical Property of ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate

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Technology Process of ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate

There total 1 articles about ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₁₃NO₃ClBr*HCl

: 3392-07-2
tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate

: 290826-63-0
ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2007.03.034

Reference yield: 81.0%

: 290826-63-0
ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate

: ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 1h;

Reference yield:

: 290826-63-0
ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-(tert-butoxycarbonyl)glycyl]amino}propanoate

: 727417-38-1
C₂₁H₂₂BrClN₆O₆C₂H₄

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / ethanol / Heating

2.1: isobutyl chloroformate; N-methylmorpholine / dimethylformamide / 0.25 h / 0 °C

2.2: N-methylmorpholine / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.03.034