(1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt

Base Information

• Chemical Name: (1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt
• CAS No.: 1200605-71-5
• Molecular Formula: C₈H₈O₃*C₈H₁₀F₂N₂O
• Molecular Weight: 340.327
• Mol file: 1200605-71-5.mol

Synonyms:(1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt

Chemical Property of (1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt

There total 4 articles about (1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

1-(3,5-difluoropyridin-2-yl)-N-hydroxy-2-methoxyethanimine (1075757-31-1) + (R)-Mandelic Acid (611-71-2) → (S)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt (1200605-74-8) + (1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt (1200605-71-5)

Guidance literature:

1-(3,5-difluoropyridin-2-yl)-N-hydroxy-2-methoxyethanimine; With hydrogen; palladium on activated charcoal; In ethyl acetate; at 40 ℃; for 1h; under 3750.38 Torr;

(R)-Mandelic Acid; In ethyl acetate; at 18 - 25 ℃;

Reference yield:

1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (1075757-32-2,1075757-20-8) + (R)-Mandelic Acid (611-71-2) → (1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt (1200605-71-5)

Guidance literature:

In ethyl acetate;

Reference yield:

3,5-difluoropyridine (71902-33-5) → (1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt (1200605-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -72 - 25 °C

1.2: 18 - 25 °C

1.3: 18 - 25 °C

2.1: hydroxylamine hydrochloride; triethylamine / ethanol / 18 - 50 °C

3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 1 h / 40 °C / 3750.38 Torr

3.2: 18 - 25 °C

With hydroxylamine hydrochloride; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;

upstream raw materials:

1-(3,5-difluoropyridin-2-yl)-N-hydroxy-2-methoxyethanimine

(R)-Mandelic Acid

1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine

1-(3,5-difluoropyridin-2-yl)-2-methoxyethanone

Refernces

• 1、 -. "TRICYCLIC 2,4-DIAMIN0-L,3,5-TRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER AND MYELOPROLIFERATIVE DISORDERS". Page/Page column 70. . Retrieved 2010/01/07.