ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate

Base Information

Chemical Name:ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate
CAS No.:1380805-73-1
Molecular Formula:C₃₆H₃₆Cl₂F₂N₂O₄
Molecular Weight:669.596
Hs Code.:

ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate

Synonyms:ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate

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Chemical Property of ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate

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Technology Process of ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate

There total 4 articles about ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 252352-73-1
ethyl 3-methoxy-4-iodobenzoate

: 1380805-42-4
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-prop-2-ynyl-pyrrolidine-3-carbonitrile

: 1380805-73-1
ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In toluene; at 25 ℃; for 16h; Darkness;

Reference yield:

: 1354693-60-9
rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1380805-73-1
ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; sodium tetrahydroborate; lithium chloride / tetrahydrofuran / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / 14 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

4: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / 25 °C / Darkness

With methanol; sodium tetrahydroborate; copper(l) iodide; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; lithium chloride; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 1380805-27-5
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidine-3-carbonitrile

: 1380805-73-1
ethyl 4-(3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl)-3-methoxy-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 14 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

3: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / 25 °C / Darkness

With copper(l) iodide; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; toluene;