3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline

Base Information

Chemical Name:3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline
CAS No.:1352036-22-6
Molecular Formula:C₂₈H₂₉NO₂
Molecular Weight:411.544
Hs Code.:

Synonyms:3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline

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Chemical Property of 3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline

There total 4 articles about 3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1310109-78-4
3-(6,7-dimethoxy-1-methylisoquinolin-3-yl)phenyl trifluoromethanesulfonate

: 123324-71-0
p-tert-butylphenylboronic acid

: 1352036-22-6
3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline

Guidance literature:: With potassium carbonate; palladium diacetate; XPhos; In water; acetonitrile; at 95 ℃; for 2h;

Reference yield:

: 16535-98-1
3-hydroxy-6,7-dimethoxy-1-methylisoquinoline

: 1352036-22-6
3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / -78 °C

2: caesium carbonate / palladium diacetate; XPhos / acetonitrile; water / 5 h / 100 °C

3: triethylamine / dichloromethane / 0.5 h / -78 °C

4: potassium carbonate / palladium diacetate; XPhos / acetonitrile; water / 2 h / 95 °C

With potassium carbonate; caesium carbonate; triethylamine; palladium diacetate; XPhos; In dichloromethane; water; acetonitrile;

Reference yield:

: 1254068-06-8
3-(6,7-dimethoxy-1-methylisoquinolin-3-yl)phenol

: 1352036-22-6
3-[4'-(tert-butyl)-[1,1'-biphenyl]-3-yl]-6,7-dimethoxy-1-methylisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / -78 °C

2: potassium carbonate / palladium diacetate; XPhos / acetonitrile; water / 2 h / 95 °C

With potassium carbonate; triethylamine; palladium diacetate; XPhos; In dichloromethane; water; acetonitrile;