(+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate

Base Information

Chemical Name:(+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate
CAS No.:1297552-55-6
Molecular Formula:C₂₆H₃₀Cl₂F₃NO₃
Molecular Weight:532.43
Hs Code.:

Synonyms:(+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate

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Chemical Property of (+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate

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Technology Process of (+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate

There total 6 articles about (+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297550-39-0
(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl chloride

: 1297551-22-4
(-)-tert-butyl (2R)-3-(3-amino-4-chloro-2-methylphenyl)-2-methylpropanoate

: 1297552-55-6
(+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -10 - 20 ℃; for 2h;

Reference yield:

: 55289-36-6
3-bromo-2-methylaniline

: 1297552-55-6
(+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / acetonitrile / 7 h / 60 °C

2.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 2 h / 150 °C / Inert atmosphere

3.1: iodine; magnesium / methanol / 20 °C

3.2: Cooling with ice

3.3: pH 10

4.1: Daicel Chiralpak OJ-H / isopropyl alcohol; 2-Methylpentane / 22 °C / Resolution of racemate

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -10 - 20 °C

With N-chloro-succinimide; iodine; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; 2-Methylpentane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1007226-77-8
3-bromo-6-chloro-2-methylaniline

: 1297552-55-6
(+)-tert-butyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-butanoyl]amino}-2-methylphenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 2 h / 150 °C / Inert atmosphere

2.1: iodine; magnesium / methanol / 20 °C

2.2: Cooling with ice

2.3: pH 10

3.1: Daicel Chiralpak OJ-H / isopropyl alcohol; 2-Methylpentane / 22 °C / Resolution of racemate

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -10 - 20 °C

With iodine; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; 2-Methylpentane; N,N-dimethyl-formamide; isopropyl alcohol;