N²-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate

Base Information

• Chemical Name: N²-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate
• CAS No.: 130761-76-1
• Molecular Formula: C₂₆H₃₂N₂O₈
• Molecular Weight: 500.549
• Mol file: 130761-76-1.mol

Synonyms:N²-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate

Chemical Property of N²-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate

There total 1 articles about N²-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(S)-N-(tert-butoxycarbonyl)serine (3262-72-4) + D-aspartic acid dibenzyl ester (4079-59-8) → N2-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate (130761-76-1)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane;

DOI:10.1021/jm00107a013

Reference yield:

N2-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate (130761-76-1) → (R)-2-((S)-2-Amino-3-hydroxy-propionylamino)-succinic acid dibenzyl ester

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h;

DOI:10.1021/jm00107a013

Reference yield:

N2-(tert-butyloxycarbonyl)-L-seryl-1,4-dibenzyl-D-aspartate (130761-76-1) → N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate (130761-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 1 h

2: 54 percent / 2-ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline (EEDQ) / CH₂Cl₂

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm00107a013

upstream raw materials:

(S)-N-(tert-butoxycarbonyl)serine

D-aspartic acid dibenzyl ester

Downstream raw materials:

N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate