6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone

Base Information

• Chemical Name: 6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone
• CAS No.: 37665-52-4
• Molecular Formula: C₁₆H₁₅ClN₂O₂
• Molecular Weight: 302.76
• Mol file: 37665-52-4.mol

Synonyms:6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone

Chemical Property of 6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone

There total 4 articles about 6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

9-chloro-10b-phenyl-2,3,6,19b-tetrahydro-5H-oxazolo<3,2-c>quinazolin-5-one (27772-51-6) → 6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone (37665-52-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 3h; Ambient temperature;

DOI:10.1248/cpb.29.2135

Reference yield: 86.0%

6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone (80171-01-3) → 6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone (37665-52-4)

Guidance literature:

With sodium tetrahydroborate; In N,N-dimethyl-formamide; for 3h; Ambient temperature;

DOI:10.1248/cpb.29.2135

Reference yield:

5-chloro-2-trichloroacetylaminobenzophenone (26381-66-8) → 6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-2(1H)-quinazolinone (37665-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / dimethylsulfoxide / 2 h / 90 °C

2: 99 percent / NaBH₄ / ethanol / 3 h / Ambient temperature

With sodium tetrahydroborate; In ethanol; dimethyl sulfoxide;

DOI:10.1248/cpb.29.2135

upstream raw materials:

9-chloro-10b-phenyl-2,3,6,19b-tetrahydro-5H-oxazolo<3,2-c>quinazolin-5-one

6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

5-chloro-2-trichloroacetylaminobenzophenone

Downstream raw materials:

3-(2-hydroxy-ethyl)-4-phenyl-3,4-dihydro-1H-quinazolin-2-one