N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

Base Information

Chemical Name:N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide
CAS No.:1586041-58-8
Molecular Formula:C₂₀H₂₀F₃N₅O₂S
Molecular Weight:451.472
Hs Code.:

Synonyms:N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

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Chemical Property of N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

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Technology Process of N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

There total 9 articles about N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: tert-butyl ((3S,4R)-7-(4-(2-(2,6-difluorophenyl)thiazole-4-carboxamido)-1-methyl-1H-pyrazol-5-yl)-3-fluorooxepan-4-yl)carbamate

: 1586041-58-8
N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

Guidance literature:: With sulfuric acid; methoxybenzene; In water; at 55 ℃; for 1h; Large scale;

Reference yield:

: 1017452-64-0
2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid

: 1586044-66-7
tert-butyl ((3R,4S,7R)-3-fluoro-7-(1-methyl-4-nitro-1H-pyrazol-5-yl)oxepan-4-yl)carbamate

: 1586041-58-8
N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

Guidance literature:

Reference yield:

: 3-fluoro-7-(1-methyl-4-nitro-1H-pyrazol-5-yl)oxepan-4-amine

: 1586041-58-8
N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / 2-methyltetrahydrofuran / 2 h / 20 °C / Large scale

2.1: CHIRALPAK AD-H / Resolution of racemate; Large scale

3.1: hydrogen; 1 % platinum on carbon / ethanol; water / 500 °C / 15001.5 Torr / Autoclave

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.75 h / Large scale

4.2: 0.5 h / Large scale

5.1: sulfuric acid; methoxybenzene / water / 1 h / 55 °C / Large scale

With potassium phosphate; 1 % platinum on carbon; sulfuric acid; hydrogen; methoxybenzene; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water;