3-Acetyl-6β-(acetylthio)-N-(cyclopropylmethyl)-14-hydroxynormorphine

Base Information

• Chemical Name: 3-Acetyl-6β-(acetylthio)-N-(cyclopropylmethyl)-14-hydroxynormorphine
• CAS No.: 130178-41-5
• Molecular Formula: C₂₄H₂₉NO₅S
• Molecular Weight: 443.564
• Mol file: 130178-41-5.mol

Synonyms:3-Acetyl-6β-(acetylthio)-N-(cyclopropylmethyl)-14-hydroxynormorphine

Chemical Property of 3-Acetyl-6β-(acetylthio)-N-(cyclopropylmethyl)-14-hydroxynormorphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Acetyl-6β-(acetylthio)-N-(cyclopropylmethyl)-14-hydroxynormorphine

There total 1 articles about 3-Acetyl-6β-(acetylthio)-N-(cyclopropylmethyl)-14-hydroxynormorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

14-hydroxydihydrocodeine (7183-69-9) → 3-Acetyl-6β-(acetylthio)-N-(cyclopropylmethyl)-14-hydroxynormorphine (130178-41-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 100 °C

2: CHCl₃ / Heating

3: 25percent H₂SO₄ / Heating

4: K₂CO₃ / dimethylformamide / 100 °C

5: Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 0 °C

6: BBr₃ / CHCl₃ / 20 °C

7: Et₃N / CH₂Cl₂

With di-isopropyl azodicarboxylate; sulfuric acid; boron tribromide; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.1441

upstream raw materials:

14-hydroxydihydrocodeine