(+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate

Base Information

Chemical Name:(+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate
CAS No.:1393126-55-0
Molecular Formula:C₂₃H₂₃F₃N₂O₃
Molecular Weight:432.442
Hs Code.:

Synonyms:(+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate

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Technology Process of (+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate

There total 4 articles about (+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1393125-46-6
(+/-)-methyl 4-(1-(4-bromophenyl)-3-methylbutoxy)benzoate

: 33468-69-8
4-(trifluoromethyl)-1H-imidazole

: 1393126-55-0
(+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate

Guidance literature:: With potassium carbonate; copper(l) iodide; 8-quinolinol; In dimethyl sulfoxide; at 100 ℃; Inert atmosphere;

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1393126-55-0
(+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: TurboGrignard / tetrahydrofuran / 0.58 h / -40 °C

1.2: 1 h / -40 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 100 °C / Inert atmosphere

With TurboGrignard; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; copper(l) iodide; 8-quinolinol; In tetrahydrofuran; dimethyl sulfoxide; 1.2: Grignard Reaction / 2.1: Mitsunobu reaction;

Reference yield:

: 590-86-3
isovaleraldehyde

: 1393126-55-0
(+/-)-methyl 4-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)butoxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: TurboGrignard / tetrahydrofuran / 0.58 h / -40 °C

1.2: 1 h / -40 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 100 °C / Inert atmosphere

With TurboGrignard; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; copper(l) iodide; 8-quinolinol; In tetrahydrofuran; dimethyl sulfoxide; 1.2: Grignard Reaction / 2.1: Mitsunobu reaction;