N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide

Base Information

• Chemical Name: N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide
• CAS No.: 220306-96-7
• Molecular Formula: C₁₉H₂₅NO₄S
• Molecular Weight: 363.478

Synonyms:N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide

Chemical Property of N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide

Chemical Property:

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Technology Process of N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide

There total 1 articles about N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(S)-3-Benzyloxy-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid methyl ester → N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide (220306-96-7)

Guidance literature:

With diisobutylaluminium hydride; In chloroform; toluene; at -78 ℃; for 1h;

DOI:10.1039/a806882h

Reference yield:

N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide (220306-96-7) → (Z)-(S)-5-Benzyloxy-4-(2,4,6-trimethyl-benzenesulfonylamino)-pent-2-enoic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) (COCl)2, DMSO, 2.) (i-Pr)2NEt / 1.) CHCl₃, hexane, -78 deg C, 30 min, 2.) -78 to 0 deg C, 30 min

2: CHCl₃ / 1 h / 0 - 20 °C

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In chloroform;

DOI:10.1039/a806882h

Reference yield:

N-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-2,4,6-trimethyl-benzenesulfonamide (220306-96-7) → (E)-(S)-5-Benzyloxy-4-(2,4,6-trimethyl-benzenesulfonylamino)-pent-2-enoic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) (COCl)2, DMSO, 2.) (i-Pr)2NEt / 1.) CHCl₃, hexane, -78 deg C, 30 min, 2.) -78 to 0 deg C, 30 min

2: CHCl₃ / 1 h / 0 - 20 °C

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In chloroform;

DOI:10.1039/a806882h

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