4-(4-nitrophenyl)-1-piperazinecarbothioic acid isobutylamide

Base Information

• Chemical Name: 4-(4-nitrophenyl)-1-piperazinecarbothioic acid isobutylamide
• CAS No.: 412332-12-8
• Molecular Formula: C₁₅H₂₂N₄O₂S
• Molecular Weight: 322.431
• Mol file: 412332-12-8.mol

Synonyms:4-(4-nitrophenyl)-1-piperazinecarbothioic acid isobutylamide

Chemical Property of 4-(4-nitrophenyl)-1-piperazinecarbothioic acid isobutylamide

Chemical Property:

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Technology Process of 4-(4-nitrophenyl)-1-piperazinecarbothioic acid isobutylamide

There total 1 articles about 4-(4-nitrophenyl)-1-piperazinecarbothioic acid isobutylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-Nitrophenyl)piperazine (6269-89-2) + isobutyl isocyanate (1873-29-6) → 4-(4-nitrophenyl)-1-piperazinecarbothioic acid isobutylamide (412332-12-8)

Guidance literature:

In toluene; at 20 ℃; for 2h;

Reference yield: 69.0%

4-(4-nitrophenyl)-1-piperazinecarbothioic acid isobutylamide (412332-12-8) → 4-(4-aminophenyl)-1-piperazinecarbothioic acid isobutylamide (412332-13-9)

Guidance literature:

With tin(ll) chloride; In ethanol; at 72 ℃; for 19h;

upstream raw materials:

1-(4-Nitrophenyl)piperazine

isobutyl isocyanate

Downstream raw materials:

4-(4-aminophenyl)-1-piperazinecarbothioic acid isobutylamide

Refernces