5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine

Base Information

Chemical Name:5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine
CAS No.:1446018-06-9
Molecular Formula:C₂₅H₂₃FN₂O₂S
Molecular Weight:434.534
Hs Code.:

Synonyms:5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine

Chemical Property:

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Technology Process of 5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine

There total 6 articles about 5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₁FN₂O₂S

: 1446018-06-9
5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃;
DOI:10.1016/j.ejmech.2014.07.072

Reference yield:

: 886620-76-4
3-(4'-fluorophenyl)-1-(4''-methoxyphenyl)propan-1-one

: 1446018-06-9
5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride; bromine / chloroform / 6 h / 20 °C

2: sodium acetate / ethanol / 80 °C

3: toluene-4-sulfonic acid / toluene / 130 °C

4: sodium tetrahydroborate / ethanol / 20 °C

With aluminum (III) chloride; sodium tetrahydroborate; bromine; sodium acetate; toluene-4-sulfonic acid; In ethanol; chloroform; toluene;
DOI:10.1016/j.ejmech.2014.07.072

Reference yield:

: 459-31-4
3-(4-fluorophenyl)propanoic acid

: 1446018-06-9
5-(4-fluorobenzyl)-N-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / Reflux

2: aluminum (III) chloride / dichloromethane

3: aluminum (III) chloride; bromine / chloroform / 6 h / 20 °C

4: sodium acetate / ethanol / 80 °C

5: toluene-4-sulfonic acid / toluene / 130 °C

6: sodium tetrahydroborate / ethanol / 20 °C

With aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; bromine; sodium acetate; toluene-4-sulfonic acid; In ethanol; dichloromethane; chloroform; toluene;
DOI:10.1016/j.ejmech.2014.07.072