{(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride

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Chemical Name:{(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride
CAS No.:107540-39-6
Molecular Formula:C₂₄H₃₂N₃O₈P*ClH
Molecular Weight:557.968
Hs Code.:

Synonyms:{(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride

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Chemical Property of {(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride

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Technology Process of {(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride

There total 4 articles about {(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 107540-38-5
Z-Ser-Leu-Gly-OMe

: 107540-39-6
{(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; ethanol; for 18h; under 1551.4 Torr;
DOI:10.1021/jo00385a023

Reference yield:

: 5084-98-0,62188-57-2,109453-36-3
methyl N-benzyloxycarbonyl-L-leucylglicynate

: 107540-39-6
{(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂, 2N HCl / Pd/C / methanol; ethanol / 18 h / 1551.4 Torr

2: 66 percent / 1-hydroxybenzotriazole (HOBt), N-methylmorpholine, dicyclohexylcarbodiimide (DCC) / dimethylformamide / 1.) -10 deg C, 1 h, 2.) room temp., 18 h

3: 94 percent / pyridine / 1.) -10 deg C, 2.5 h, 2.) 4 deg C, 18 h

4: 95 percent / H₂, 2N HCl / Pd/C / methanol; ethanol / 18 h / 1551.4 Torr

With 4-methyl-morpholine; pyridine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00385a023

Reference yield:

: 107540-26-1
Z-Ser-Leu-Gly-OMe

: 107540-39-6
{(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine / 1.) -10 deg C, 2.5 h, 2.) 4 deg C, 18 h

2: 95 percent / H₂, 2N HCl / Pd/C / methanol; ethanol / 18 h / 1551.4 Torr

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jo00385a023