biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Base Information

Chemical Name:biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester
CAS No.:1253582-37-4
Molecular Formula:C₃₆H₄₄N₄O₅
Molecular Weight:612.769
Hs Code.:

Synonyms:biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

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Chemical Property of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

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Technology Process of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

There total 12 articles about biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: biphenyl-2-ylcarbamic acid 1-(2-{[3-(4-hydroxymethyl-2,5-dimethylphenylcarbamoyl)propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

: 1253582-37-4
biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Guidance literature:: With pyridine-SO₃ complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 954136-51-7
dibenzyl-(4-[1,3]dioxolan-2-yl-2,5-dimethyl-phenyl)amine

: 1253582-37-4
biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; sodium hydrogencarbonate / palladium 10% on activated carbon / ethanol; water; ethyl acetate / 3 h / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

2.2: 3 h / 20 °C

3.1: pyridine-SO₃ complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

With pyridine-SO₃ complex; hydrogen; sodium hydrogencarbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 953394-03-1
dibenzyl-(4-iodo-2,5-dimethylphenyl)amine

: 1253582-37-4
biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-formyl-2,5-dimethyl-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexanes; toluene / 0.75 h / -15 °C / Inert atmosphere

1.2: 2.17 h

2.1: toluene-4-sulfonic acid / toluene / 80 °C / Inert atmosphere

3.1: hydrogen; sodium hydrogencarbonate / palladium 10% on activated carbon / ethanol; water; ethyl acetate / 3 h / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.2: 3 h / 20 °C

5.1: pyridine-SO₃ complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

With n-butyllithium; pyridine-SO₃ complex; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In hexanes; ethanol; dichloromethane; water; ethyl acetate; toluene;