3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Base Information

Chemical Name:3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
CAS No.:1262106-64-8
Molecular Formula:C₂₇H₂₉N₅O₃
Molecular Weight:471.559
Hs Code.:

Synonyms:3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

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Chemical Property of 3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

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Technology Process of 3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

There total 8 articles about 3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 110-91-8,99108-56-2
morpholine

: 1262106-80-8
8-(4-bromophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

: 1262106-64-8
3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; DavePhos; In toluene; at 100 ℃;
DOI:10.1016/j.bmcl.2015.07.101

Reference yield:

: C₂₃H₂₃BrClN₃O₄

: 1262106-64-8
3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / tetrachloromethane

2: sodium azide

3: triphenylphosphine / water

4: acetic acid

5: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / toluene / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; acetic acid; triphenylphosphine; sodium t-butanolate; DavePhos; In tetrachloromethane; water; toluene;
DOI:10.1016/j.bmcl.2015.07.101

Reference yield:

: C₂₃H₂₁BrN₆O₃

: 1262106-64-8
3-[3-methoxy-4-(2-methyl-1;3-oxazol-5-yl)phenyl]-8-(4-morpholin-4-ylphenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / water

2: acetic acid

3: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / toluene / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; acetic acid; triphenylphosphine; sodium t-butanolate; DavePhos; In water; toluene;
DOI:10.1016/j.bmcl.2015.07.101