Technology Process of O-(2S,3R,4R,5S)-5-(benzyloxy)-1-(tert-butyldimethylsilyloxy)-2,4-dimethylheptan-3-yl S-methylcarbonodithioate
There total 5 articles about O-(2S,3R,4R,5S)-5-(benzyloxy)-1-(tert-butyldimethylsilyloxy)-2,4-dimethylheptan-3-yl S-methylcarbonodithioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
3.1: methanol; sodium tetrahydroborate / 1 h / 0 °C / Inert atmosphere
4.1: 1H-imidazole / dichloromethane / 2 h / 0 °C / Inert atmosphere
5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
5.2: 0.5 h / 0 °C / Inert atmosphere
5.3: 0 - 20 °C / Inert atmosphere
With
1H-imidazole; methanol; sodium tetrahydroborate; titanium tetrachloride; sodium hydride; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1016/j.tetasy.2011.11.013
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -15 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere
3.2: 0.5 h / -78 °C / Inert atmosphere
4.1: methanol; sodium tetrahydroborate / 1 h / 0 °C / Inert atmosphere
5.1: 1H-imidazole / dichloromethane / 2 h / 0 °C / Inert atmosphere
6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
6.2: 0.5 h / 0 °C / Inert atmosphere
6.3: 0 - 20 °C / Inert atmosphere
With
1H-imidazole; methanol; sodium tetrahydroborate; titanium tetrachloride; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane; toluene; mineral oil;
DOI:10.1016/j.tetasy.2011.11.013
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanol; sodium tetrahydroborate / 1 h / 0 °C / Inert atmosphere
2.1: 1H-imidazole / dichloromethane / 2 h / 0 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
3.2: 0.5 h / 0 °C / Inert atmosphere
3.3: 0 - 20 °C / Inert atmosphere
With
1H-imidazole; methanol; sodium tetrahydroborate; sodium hydride;
In
tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1016/j.tetasy.2011.11.013
