methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate

Base Information

Chemical Name:methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate
CAS No.:1609024-92-1
Molecular Formula:C₂₃H₁₅F₃N₂O₂
Molecular Weight:408.38
Hs Code.:

Synonyms:methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate

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Chemical Property of methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate

Chemical Property:

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Technology Process of methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate

There total 8 articles about methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1268867-65-7
methyl 3-chloro-2-phenylquinoxaline-6-carboxylate

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1609024-92-1
methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; Sealed tube; Inert atmosphere;

Reference yield:

: 1268865-04-8
methyl 4-((2-methoxy-2-oxo-1-phenylethyl)amino)-3-nitrobenzoate

: 1609024-92-1
methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium chloride; iron / methanol / 2 h / Reflux

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 3 h / 20 °C

3: phosphorus pentachloride / acetonitrile / 5 h / Reflux

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Sealed tube; Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; iron; ammonium chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; methanol; toluene; acetonitrile; 4: |Suzuki Coupling;

Reference yield:

: 23121-25-7
methyl 3-oxo-2-phenyl-1,2,3,4-tetrahydroquinoxaline-6-carboxylate

: 1609024-92-1
methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 3 h / 20 °C

2: phosphorus pentachloride / acetonitrile / 5 h / Reflux

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Sealed tube; Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; toluene; acetonitrile; 3: |Suzuki Coupling;