1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:1589503-93-4
Molecular Formula:C₂₇H₂₄F₂N₆O₃S
Molecular Weight:550.589
Hs Code.:

Synonyms:1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

Suppliers and Price of 1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Boiling Point:769.2±70.0 °C(Predicted)
Density:1.425±0.06 g/cm3(Predicted)

Purity/Quality:: 99.9% ^*data from raw suppliers

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Technology Process of 1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 15 articles about 1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-nitrophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 1589503-93-4
1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; ethyl acetate; at 25 ℃; for 2.5h;

Reference yield:

: 697-73-4
2,6-difluorobenzyl chloride

: 1589503-93-4
1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 100 °C

2: potassium carbonate / 3 h / 60 °C

3: tetrahydrofuran / 5 h / 70 °C

4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / Reflux

5: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

6: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1-(2,6-difluorobenzyl)-3-(6-methoxypyridazin-3-yl)-5-methyl-6-(4-nitrophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 1589503-93-4
1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

3: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;