2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole

Base Information

• Chemical Name: 2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole
• CAS No.: 114772-41-7
• Molecular Formula: C₂₃H₂₅ClN₂O₃
• Molecular Weight: 412.916
• Mol file: 114772-41-7.mol

Synonyms:2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole

Chemical Property of 2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole

There total 3 articles about 2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-butyl-4(5)-chloro-5(4)-hydroxymethyl imidazole + methyl 4'-(bromomethyl)-[1,1'-biphenyl]-3-carboxylate (114772-37-1) → 2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole (114772-41-7)

Guidance literature:

With sodium methylate; In N-methyl-acetamide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

methyl 3-iodo-benzoate (618-91-7) → 2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole (114772-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 35 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, azobisisobutyronitrile / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 40 deg C, 4 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium methylate; copper; In tetrachloromethane;

DOI:10.1021/jm00167a008

Reference yield:

methyl 4′-methyl-[1,1′-biphenyl]-3-carboxylate (114772-33-7) → 2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole (114772-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromosuccinimide, azobisisobutyronitrile / CCl₄ / 3 h / Heating

2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 40 deg C, 4 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium methylate; In tetrachloromethane;

DOI:10.1021/jm00167a008

upstream raw materials:

methyl 3-iodo-benzoate

methyl 4′-methyl-[1,1′-biphenyl]-3-carboxylate

methyl 4'-(bromomethyl)-[1,1'-biphenyl]-3-carboxylate

Downstream raw materials:

2-butyl-1-<(3'-carboxybiphenyl-4-yl)methyl>-4-chloro-5-(hydroxymethyl)imidazole

2-butyl-1-<(3'-carbomethoxybiphenyl-4-yl)methyl>-5-(hydroxymethyl)imidazole

2-butyl-1-<(3'-carboxybiphenyl-4-yl)methyl>-5-(hydroxymethyl)imidazole

5-(acetoxymethyl)-2-butyl-1-<(3'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole