Technology Process of 2-O-acetyl-3,4,6-tri-O-benzyl-α-D-galactopyranosyl fluoride
There total 10 articles about 2-O-acetyl-3,4,6-tri-O-benzyl-α-D-galactopyranosyl fluoride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2,6-lutidine, Bu4NBr / nitromethane / 20 h / 40 °C
2: 0.1 M NaOMe / methanol / 1 h / Ambient temperature
3: 80percent NaH / dimethylformamide / 15 h / Ambient temperature
4: 1.) conc. H2SO4, 2.) pyridine / 1.) 1,4-dioxane, reflux, 2 h, 2.) RT, 16 h
5: 68 percent / HF, pyridine / CH2Cl2 / 3 h / 0 °C
With
pyridine; 2,6-dimethylpyridine; sulfuric acid; hydrogen fluoride; tetrabutylammomium bromide; sodium methylate; sodium hydride;
In
methanol; nitromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(93)84071-D
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 0.1 M NaOMe / methanol / 1 h / Ambient temperature
2: 80percent NaH / dimethylformamide / 15 h / Ambient temperature
3: 1.) conc. H2SO4, 2.) pyridine / 1.) 1,4-dioxane, reflux, 2 h, 2.) RT, 16 h
4: 68 percent / HF, pyridine / CH2Cl2 / 3 h / 0 °C
With
pyridine; sulfuric acid; hydrogen fluoride; sodium methylate; sodium hydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(93)84071-D
