(±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Base Information

Chemical Name:(±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine
CAS No.:1616599-04-2
Molecular Formula:C₂₁H₂₂ClN₅O₃
Molecular Weight:427.89
Hs Code.:

Synonyms:(±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine

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Chemical Property of (±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine

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Technology Process of (±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine

There total 10 articles about (±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616599-03-1
(±)-1-{5-[(2,4-dimethoxybenzyl)amino]-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-2-yl}ethyl methanesulfonate

: 1616599-04-2
(±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Guidance literature:: With lithium chloride; In acetone; for 24h; Reflux;

Reference yield:

: 1616599-01-9
5-[(2,4-dimethoxybenzyl)amino]-7-methoxy[1,2,4]triazolo[1,5-c]quinazoline-2-carbaldehyde

: 1616599-04-2
(±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.5 h / 0 - 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

3: lithium chloride / acetone / 24 h / Reflux

With N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; acetone;

Reference yield:

: 3177-80-8
2-amino-3-methoxybenzoic acid

: 1616599-04-2
(±)-2-(1-chloroethyl)-N-(2,4-dimethoxybenzyl)-7-methoxy[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid / water / 4 h / 55 - 60 °C

2: trichlorophosphate / 16 h / 105 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 65 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

5: N,O-bis-(trimethylsilyl)-acetamide / 130 °C / Sealed tube

6: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

7: tetrahydrofuran / 1.5 h / 0 - 20 °C / Cooling with ice

8: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

9: lithium chloride / acetone / 24 h / Reflux

With N,O-bis-(trimethylsilyl)-acetamide; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;