N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide
• CAS No.: 1310058-04-8
• Molecular Formula: C₃₉H₅₂F₃NO₄
• Molecular Weight: 655.841
• Mol file: 1310058-04-8.mol

Synonyms:N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide

Chemical Property of N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide

There total 1 articles about N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

trityl chloride (76-83-5) + 2,2,2-trifluoro-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]acetamide (354149-81-8) → N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide (1310058-04-8)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0030-1258437

Reference yield:

N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide (1310058-04-8) → C39H50F3NO5S

Guidance literature:

With thionyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0030-1258437

Reference yield:

N-[(2S,3S,4R)-3,4-dihydroxy-1-(trityloxy)octadecan-2-yl]-2,2,2-trifluoroacetamide (1310058-04-8) → (2S,3S,4S)-1-(trityloxy)-2-[N-(trifluoroacetyl)amino]octadecan-3,4-cyclic sulfate

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: sodium periodate; ruthenium(III) chloride trihydrate / tetrachloromethane; water; acetonitrile / 2 h / 20 °C / Inert atmosphere

With sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; triethylamine; In tetrachloromethane; dichloromethane; water; acetonitrile;

DOI:10.1055/s-0030-1258437

upstream raw materials:

trityl chloride

2,2,2-trifluoro-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]acetamide