5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine

Base Information

Chemical Name:5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine
CAS No.:1227243-09-5
Molecular Formula:C₂₀H₁₇ClN₄
Molecular Weight:348.835
Hs Code.:

Synonyms:5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine

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Chemical Property of 5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine

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Technology Process of 5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine

There total 3 articles about 5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 827614-64-2
2-aminopyridine-5-boronic acid pinacol ester

: 1227165-24-3
carbonic acid 8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester

: 1227243-09-5
5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine

Guidance literature:: With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); 1,5-bis-(diphenylphosphino)pentane; In N,N-dimethyl-formamide; at 90 ℃; for 2h;

Reference yield:

: 1227165-23-2
[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-yl]-methanol

: 1227243-09-5
5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / -10 - 20 °C

1.2: -20 - 20 °C / Inert atmosphere

2.1: potassium carbonate / bis(η3-allyl-μ-chloropalladium(II)); 1,5-bis-(diphenylphosphino)pentane / N,N-dimethyl-formamide / 2 h / 90 °C

With sodium hydride; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); 1,5-bis-(diphenylphosphino)pentane; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1227165-21-0
8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester

: 1227243-09-5
5-[8-(3-chloro-phenyl)-3-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -78 - 20 °C / Inert atmosphere

1.2: 0.33 h / 20 °C / Cooling with ice; Acidic aqueous solution

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / -10 - 20 °C

2.2: -20 - 20 °C / Inert atmosphere

3.1: potassium carbonate / bis(η3-allyl-μ-chloropalladium(II)); 1,5-bis-(diphenylphosphino)pentane / N,N-dimethyl-formamide / 2 h / 90 °C

With sodium hydride; diisobutylaluminium hydride; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); 1,5-bis-(diphenylphosphino)pentane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;