4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde

Base Information

Chemical Name:4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde
CAS No.:737800-13-4
Molecular Formula:C₃₈H₃₈Cl₂O₈
Molecular Weight:693.621
Hs Code.:

Synonyms:4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde

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Chemical Property of 4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde

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Technology Process of 4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde

There total 7 articles about 4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 737800-12-3
[3,5-bis-benzyloxy-2-hydroxymethyl-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanol

: 737800-13-4
4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde

Guidance literature:: With dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In toluene;
DOI:10.1016/j.tetlet.2004.05.063

Reference yield:

: 870-63-3
prenyl bromide

: 737800-13-4
4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / -78 °C

1.2: 78 percent / 1,2-dimethoxy-ethane / 0 °C

2.1: n-BuLi / -78 °C

2.2: 62 percent / 1,2-dimethoxy-ethane / 0 °C

3.1: 86 percent / LiAlH₄ / tetrahydrofuran

4.1: 99 percent / imidazole / dimethylformamide

5.1: MeI / 40 °C

5.2: NaBH₄ / methanol; tetrahydrofuran

5.3: 69 percent / aq. AcOH / tetrahydrofuran

6.1: 99 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

7.1: 100 percent / TBAF / tetrahydrofuran

8.1: 53 percent / IBX; DMSO / toluene

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; dimethyl sulfoxide; methyl iodide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2004.05.063

Reference yield:

: 737800-16-7
[4,6-bis-benzyloxy-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-3-(3-methyl-but-2-enyl)-phenyl]-methanol

: 737800-13-4
4,6-bis-benzyloxy-2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-(3-methyl-but-2-enyl)-benzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / imidazole / dimethylformamide

2.1: MeI / 40 °C

2.2: NaBH₄ / methanol; tetrahydrofuran

2.3: 69 percent / aq. AcOH / tetrahydrofuran

3.1: 99 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

4.1: 100 percent / TBAF / tetrahydrofuran

5.1: 53 percent / IBX; DMSO / toluene

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; dimethyl sulfoxide; methyl iodide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2004.05.063