2-{4-[2-(4-amino-3-nitro-phenyl)-1⁽³⁾H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol

Base Information

• Chemical Name: 2-{4-[2-(4-amino-3-nitro-phenyl)-1⁽³⁾H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol
• CAS No.: 23470-53-3
• Molecular Formula: C₁₉H₂₂N₆O₃
• Molecular Weight: 382.422

Synonyms:2-{4-[2-(4-amino-3-nitro-phenyl)-1⁽³⁾H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol

Chemical Property of 2-{4-[2-(4-amino-3-nitro-phenyl)-1⁽³⁾H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-{4-[2-(4-amino-3-nitro-phenyl)-1⁽³⁾H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol

There total 2 articles about 2-{4-[2-(4-amino-3-nitro-phenyl)-1⁽³⁾H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 2-{4-[2-(4-amino-3-nitro-phenyl)-1(3)H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol (23470-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / ISOPROPYLAMIDE / 24 h / 120 - 125 °C / Inert atmosphere

2.1: hydrogen; acetic acid / 5%-palladium/activated carbon / ethanol / 24 h / 20 °C / Inert atmosphere

2.2: 24 h / 80 °C / Inert atmosphere

2.3: 24 h / 4 °C

With hydrogen; potassium carbonate; acetic acid; 5%-palladium/activated carbon; In ethanol; ISOPROPYLAMIDE;

Reference yield:

→ 2-{4-[2-(4-amino-3-nitro-phenyl)-1(3)H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol (23470-53-3)

Guidance literature:

Entspr. o-Phenylendiamin, 3-Nitro-4-aminobenziminoether*HCl;

Reference yield:

2-{4-[2-(4-amino-3-nitro-phenyl)-1(3)H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol (23470-53-3) → 2-{4-[2-(3,4-diamino-phenyl)-1(3)H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol (23617-83-6)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; ethyl acetate; at 20 ℃; for 24h; Inert atmosphere;

upstream raw materials:

5-chloro-2-nitroaniline

Downstream raw materials:

2-{4-[2-(3,4-diamino-phenyl)-1⁽³⁾H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol

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