rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

Base Information

Chemical Name:rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
CAS No.:1610829-45-2
Molecular Formula:C₃₁H₃₁Cl₃N₄O₅S
Molecular Weight:678.036
Hs Code.:

rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

Synonyms:rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

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Chemical Property of rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

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Technology Process of rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

There total 10 articles about rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

: 4-[(4R,5S)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

: 1610829-45-2
rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

Guidance literature:: With Whelk-O₁; In methanol; Resolution of racemate;

Reference yield:

: 939983-31-0
4-chloro-5-chlorosulfonyl-2-ethoxybenzoic acid

: 4-[(4R,5S)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

: 1610829-45-2
rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate; sodium sulfite / water / 1 h / 70 - 75 °C

1.2: 16 h / 100 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -5 - 0 °C

4.1: trichlorophosphate / toluene / Reflux

5.1: triethylamine / toluene; dichloromethane / 1.5 h / 0 - 20 °C

6.1: triethylamine / dichloromethane / 0.5 h / 0 °C

7.1: Whelk-O₁ / methanol / Resolution of racemate

With oxalyl dichloride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium sulfite; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

: 1235487-67-8
4-chloro-2-ethoxy-5-methanesulfonylbenzoic acid

: 4-[(4R,5S)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

: 1610829-45-2
rac-4-[(4S,5R)-2-(4-chloro-2-ethoxy-5-methanesulfonylphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -5 - 0 °C

3: trichlorophosphate / toluene / Reflux

4: triethylamine / toluene; dichloromethane / 1.5 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0.5 h / 0 °C

6: Whelk-O₁ / methanol / Resolution of racemate

With oxalyl dichloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; toluene;