(E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

Base Information

Chemical Name:(E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde
CAS No.:1365889-17-3
Molecular Formula:C₂₉H₂₆Cl₂N₂O₂
Molecular Weight:505.444
Hs Code.:

Synonyms:(E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

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Chemical Property of (E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

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Technology Process of (E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

There total 5 articles about (E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365889-00-4
5-(but-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 29898-32-6
2,4-dichloro-1-iodo-benzene

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 1365889-17-3
(E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

: (Z)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

Guidance literature:: 5-(but-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; With bis(pinacol)diborane; tetrakis(triphenylphosphine)platinum; In 2-methyltetrahydrofuran; at 83 ℃; for 5h; Inert atmosphere;

p-(iodophenyl)carboxaldehyde; With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 2-methyltetrahydrofuran; water; at 4 - 20 ℃; for 6h; Inert atmosphere;

2,4-dichloro-1-iodo-benzene; With potassium hydroxide; In 2-methyltetrahydrofuran; water; for 4h; Inert atmosphere; Reflux;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1365889-17-3
(E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

: (Z)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

3.1: bis(pinacol)diborane / tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 5 h / 83 °C / Inert atmosphere

3.2: 6 h / 4 - 20 °C / Inert atmosphere

3.3: 4 h / Inert atmosphere; Reflux

With copper(l) iodide; pyridinium p-toluenesulfonate; caesium carbonate; bis(pinacol)diborane; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine)platinum; palladium diacetate; In 2-methyltetrahydrofuran; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1365889-17-3
(E)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

: (Z)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

3.1: bis(pinacol)diborane / tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 5 h / 83 °C / Inert atmosphere

3.2: 6 h / 4 - 20 °C / Inert atmosphere

3.3: 4 h / Inert atmosphere; Reflux

With copper(l) iodide; pyridinium p-toluenesulfonate; caesium carbonate; bis(pinacol)diborane; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine)platinum; palladium diacetate; In 2-methyltetrahydrofuran; dichloromethane; ISOPROPYLAMIDE;