Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl

Base Information

Chemical Name:Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl
CAS No.:336192-13-3
Molecular Formula:C₁₀H₂₀N₂O₃
Molecular Weight:216.28
Hs Code.:
Mol file:336192-13-3.mol

Synonyms:Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl

Suppliers and Price of Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl

Chemical Property:

PSA：70.59000
LogP:0.95360

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl

There total 8 articles about Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 847994-36-9
(2S,4R)-N₁-(benzyloxycarbonyl)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxy-pyrrolidine

: 500733-24-4,336192-13-3
(2S,4R)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxypyrrolidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 7h; under 3102.97 Torr;
DOI:10.1039/b413542c

Reference yield:

: 64187-48-0
methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

: 500733-24-4,336192-13-3
(2S,4R)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / LiCl; NaBH₄ / tetrahydrofuran; ethanol / 20 °C

2: 75 percent / pyridine / 8 h / 20 °C

3: 96 percent / NaN₃ / dimethylformamide / 8 h / 55 °C

4: H₂ / Raney Ni / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr

5: 76 percent / Et₃N / dimethylsulfoxide / 8 h / 50 °C

6: H₂ / Pd/C / methanol / 7 h / 20 °C / 3102.89 Torr

With pyridine; sodium tetrahydroborate; sodium azide; hydrogen; triethylamine; lithium chloride; palladium on activated charcoal; nickel; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.002

Reference yield:

: 95687-41-5,1448706-36-2
(2S,4R)-N1-(benzyloxycarbonyl)-4-hydroxy-2-(hydroxymethyl)-pyrrolidine

: 500733-24-4,336192-13-3
(2S,4R)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / pyridine / 8 h / 20 °C

2: 96 percent / NaN₃ / dimethylformamide / 8 h / 55 °C

3: H₂ / Raney Ni / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr

4: 76 percent / Et₃N / dimethylsulfoxide / 8 h / 50 °C

5: H₂ / Pd/C / methanol / 7 h / 20 °C / 3102.89 Torr

With pyridine; sodium azide; hydrogen; triethylamine; palladium on activated charcoal; nickel; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.002