methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Base Information

Chemical Name:methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate
CAS No.:1265403-36-8
Molecular Formula:C₂₄H₂₆N₂O₃
Molecular Weight:390.482
Hs Code.:

Synonyms:methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

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Chemical Property of methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

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Technology Process of methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

There total 13 articles about methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1265393-37-0
methyl 2-(2-chloro-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

: 89466-08-0
2-hydroxyphenyl boronic acid

: 1265403-36-8
methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 130 ℃; for 1h; Sealed tube; Microwave irradiation;

Reference yield:

: 615-83-8
2-bromo-pentanoic acid ethyl ester

: 1265403-36-8
methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 21 h / 80 °C

2.2: 0.5 h / 20 °C

3.1: water; chloroacetic acid / 20 h / Reflux

4.1: thionyl chloride / 48 h / 0 °C / Reflux

5.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 115 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 90 °C

7.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 130 °C / Sealed tube; Microwave irradiation

With thionyl chloride; water; sodium methylate; potassium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; chloroacetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 162498-52-4
(2,4-dichloro-6-methylpyrimidin-5-yl)acetic acid methyl ester

: 1265403-36-8
methyl 2-(2-(2-hydroxyphenyl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -78 °C

2.2: 3 h / -15 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 130 °C / Sealed tube; Microwave irradiation

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;