Diethyl [α-2H]phenylmalonate

Base Information

• Chemical Name: Diethyl [α-2H]phenylmalonate
• CAS No.: 300537-13-7
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 237.26
• Mol file: 300537-13-7.mol

Synonyms:Diethyl [α-2H]phenylmalonate

Chemical Property of Diethyl [α-2H]phenylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Diethyl [α-2H]phenylmalonate

There total 1 articles about Diethyl [α-2H]phenylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

diethyl 2-phenylmalonate (83-13-6) → Diethyl [α-2H]phenylmalonate (300537-13-7)

Guidance literature:

diethyl 2-phenylmalonate; With sodium hydride; In tetrahydrofuran; for 5h; Heating;

With diclazuril; water-d2; Further stages.;

DOI:10.1039/b003941l

Reference yield: 90.0%

Diethyl [α-2H]phenylmalonate (300537-13-7) → [α-2H]Phenylmalonic acid disodium salt

Guidance literature:

With deuteriated sodium hydroxide; water-d2; In deuteromethanol; at 20 ℃; for 12h;

DOI:10.1039/b003941l

Reference yield:

Diethyl [α-2H]phenylmalonate (300537-13-7) → (R)-2-phenylacetic-2-acid

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaOD; D₂O / CH₃OD / 12 h / 20 °C

2: 92 percent / arylmalonate decarboxylase (E⁽¹⁾C₄₁₇₆) / various solvent(s) / 0.5 h / 35 °C / pH 8.5

With deuteriated sodium hydroxide; arylmalonate decarboxylase (E⁽¹⁾C₄₁₇₆); water-d2; In deuteromethanol; 1: Hydrolysis / 2: Decarboxylation;

DOI:10.1039/b003941l

upstream raw materials:

diethyl 2-phenylmalonate