diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-trimethylsilyloxypropylphosphonate

Base Information

• Chemical Name: diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-trimethylsilyloxypropylphosphonate
• CAS No.: 1202351-39-0
• Molecular Formula: C₁₈H₃₃N₄O₄PSi
• Molecular Weight: 428.544
• Mol file: 1202351-39-0.mol

Synonyms:diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-trimethylsilyloxypropylphosphonate

Chemical Property of diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-trimethylsilyloxypropylphosphonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-trimethylsilyloxypropylphosphonate

There total 1 articles about diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-trimethylsilyloxypropylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

diethyl (S)-hydroxy {(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}methylphosphonate (945676-57-3) + trimethylsilylazide (4648-54-8) → diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-hydroxypropylphosphonate (1202351-40-3) + diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-trimethylsilyloxypropylphosphonate (1202351-39-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 336h;

DOI:10.1016/j.tetasy.2009.08.032

Reference yield: 88.0%

diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-trimethylsilyloxypropylphosphonate (1202351-39-0) → diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-hydroxypropylphosphonate (1202351-40-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h;

DOI:10.1016/j.tetasy.2009.08.032

upstream raw materials:

diethyl (S)-hydroxy {(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}methylphosphonate

trimethylsilylazide

Downstream raw materials:

diethyl (1S,2S)-3-azido-2-[(R)-1-phenylethyl]amino-1-hydroxypropylphosphonate