(±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol

Base Information

Chemical Name:(±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol
CAS No.:1605318-18-0
Molecular Formula:C₁₆H₁₇FN₂O
Molecular Weight:272.322
Hs Code.:

Synonyms:(±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol

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Chemical Property of (±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol

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Technology Process of (±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol

There total 5 articles about (±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1605313-20-9
(±)-6-[(4-fluoro-phenyl)-hydroxy-methyl]-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester

: 1605318-18-0
(±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol

Guidance literature:: With hydrogenchloride; In methanol; at 50 ℃; for 19h;

Reference yield:

: 1403901-49-4
6-bromo-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester

: 1605318-18-0
(±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 0.5 h

2.1: hydrogenchloride / methanol / 19 h / 50 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; methanol; hexane;

Reference yield:

: 1403901-48-3
(5-bromo-2-iodo-pyridin-3-yl)-(2-methyl-allyl)-amine

: 1605318-18-0
(±)-(3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-6-yl)-(4-fluorophenyl)-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; palladium diacetate; tetrabutyl-ammonium chloride; sodium formate / water; dimethyl sulfoxide / 1 h / 100 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 1.75 h

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 0.5 h

4.1: hydrogenchloride / methanol / 19 h / 50 °C

With hydrogenchloride; n-butyllithium; potassium tert-butylate; tetrabutyl-ammonium chloride; sodium formate; palladium diacetate; triethylamine; In tetrahydrofuran; methanol; hexane; water; dimethyl sulfoxide;