Cyclohexanecarboxylic acid, 1-amino-5-methyl-2-(1-methylethyl)-, (1S,2S,5R)-

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 1-amino-5-methyl-2-(1-methylethyl)-, (1S,2S,5R)-
• CAS No.: 336100-66-4
• Molecular Formula: C₁₁H₂₁NO₂
• Molecular Weight: 199.293
• Mol file: 336100-66-4.mol

Synonyms:Cyclohexanecarboxylic acid, 1-amino-5-methyl-2-(1-methylethyl)-, (1S,2S,5R)-

Chemical Property of Cyclohexanecarboxylic acid, 1-amino-5-methyl-2-(1-methylethyl)-, (1S,2S,5R)-

Chemical Property:

• PSA: 63.32000
• LogP: 2.56100

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxylic acid, 1-amino-5-methyl-2-(1-methylethyl)-, (1S,2S,5R)-

There total 5 articles about Cyclohexanecarboxylic acid, 1-amino-5-methyl-2-(1-methylethyl)-, (1S,2S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5S,6S,9R)-6-isopropyl-9-methyl-1,3-diazaspiro[4.5]decane-2,4-dione (17138-09-9,17138-11-3,52153-45-4,83377-81-5) → 3-endo-Amino-3-exo-carboxy-menthan (17138-10-2,336100-66-4)

Guidance literature:

With sulfuric acid; water; at 150 ℃; for 96h; Inert atmosphere;

Reference yield:

1-amino-trans-2-isopropyl-5-methylcyclohexane-1-spiro-5'-hydantoin → 1-amino-trans-2-isopropyl-5-methylcyclohexanecarboxylc acid (336100-66-4)

Guidance literature:

With sulfuric acid;

Reference yield:

(2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → 3-endo-Amino-3-exo-carboxy-menthan (17138-10-2,336100-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; water / 17 h / 60 °C

2: sulfuric acid / water / 2 h / 150 °C

With sulfuric acid; In ethanol; water; 1: |Bucherer-Bergs Reaction;

DOI:10.1016/j.tet.2016.04.008

upstream raw materials:

(5S,6S,9R)-6-isopropyl-9-methyl-1,3-diazaspiro[4.5]decane-2,4-dione

(2R,5S)-menthone