Carbamic acid, [(1S)-1-formyl-2,2-dimethylpropyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1S)-1-formyl-2,2-dimethylpropyl]-, 1,1-dimethylethyl ester
• CAS No.: 335627-99-1
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.293
• Hs Code.: 2924199090
• Mol file: 335627-99-1.mol

Synonyms:Carbamicacid, [(1S)-1-formyl-2,2-dimethylpropyl]-, 1,1-dimethylethyl ester (9CI);[(1S)-1-Formyl-2,2-dimethylpropyl]carbamic acid tert-butyl ester

Chemical Property of Carbamic acid, [(1S)-1-formyl-2,2-dimethylpropyl]-, 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 290.0±23.0 °C(Predicted)
• PKA: 11.43±0.46(Predicted)
• PSA: 55.40000
• Density: 0.977±0.06 g/cm3(Predicted)
• LogP: 2.51560

Purity/Quality:

(S)-tert-Butyl(3,3-dimethyl-1-oxobutan-2-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-1-formyl-2,2-dimethylpropyl]-, 1,1-dimethylethyl ester

There total 10 articles about Carbamic acid, [(1S)-1-formyl-2,2-dimethylpropyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-Boc-L-tert-leucinol (153645-26-2,545433-63-4) → tert-butyl N-[(1S)-1-formyl-2,2-dimethylpropyl]carbamate (335627-99-1)

Guidance literature:

With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In dichloromethane; at -10 ℃;

DOI:10.1016/j.bmcl.2003.09.088

Reference yield: 97.0%

(4S,5R)-5-benzyloxy-3-tert-butoxycarbonyl-4-tert-butyl-2-oxazolidinone (335628-11-0) → tert-butyl N-[(1S)-1-formyl-2,2-dimethylpropyl]carbamate (335627-99-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;

DOI:10.1021/ol015535r

Reference yield: 92.0%

[1(S)-(methoxy-methyl-carbamoyl)-2,2-dimethylpropyl]-carbamic acid-tert-butyl ester (210711-68-5) → tert-butyl N-[(1S)-1-formyl-2,2-dimethylpropyl]carbamate (335627-99-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;

upstream raw materials:

(4S,5R)-5-benzyloxy-3-tert-butoxycarbonyl-4-tert-butyl-2-oxazolidinone

N-Boc-L-tert-leucinol

di-tert-butyl dicarbonate

(S)-tert-leucinol

Downstream raw materials:

N-Boc-L-tert-leucinol