3-Butynoic acid, 4-(2-aMino-4-fluoro-5-nitrophenyl)-2,2-diMethyl-, phenylMethyl ester

Base Information

• Chemical Name: 3-Butynoic acid, 4-(2-aMino-4-fluoro-5-nitrophenyl)-2,2-diMethyl-, phenylMethyl ester
• CAS No.: 1225589-66-1
• Molecular Formula: C₁₉H₁₇FN₂O₄
• Molecular Weight: 356.353
• Mol file: 1225589-66-1.mol

Synonyms:benzyl 4-(2-amino-4-fluoro-5-nitrophenyl)-2,2-dimethylbut-3-ynoate

Chemical Property of 3-Butynoic acid, 4-(2-aMino-4-fluoro-5-nitrophenyl)-2,2-diMethyl-, phenylMethyl ester

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

Benzyl4-(2-amino-4-fluoro-5-nitrophenyl)-2,2-dimethylbut-3-ynoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Butynoic acid, 4-(2-aMino-4-fluoro-5-nitrophenyl)-2,2-diMethyl-, phenylMethyl ester

There total 1 articles about 3-Butynoic acid, 4-(2-aMino-4-fluoro-5-nitrophenyl)-2,2-diMethyl-, phenylMethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-bromo-5-fluoro-4-nitroaniline (952664-69-6) + 2,2-dimethyl-3-butynoic acid benzyl ester (204588-77-2) → benzyl 4-(2-amino-4-fluoro-5-nitrophenyl)-2,2-dimethylbut-3-ynoate (1225589-66-1)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 20 - 80 ℃;

Reference yield: 90.0%

benzyl 4-(2-amino-4-fluoro-5-nitrophenyl)-2,2-dimethylbut-3-ynoate (1225589-66-1) → benzyl 2-(6-fluoro-5-nitro- 1H-indol-2-yl)-2-methylpropanoate (1152311-77-7)

Guidance literature:

palladium dichloride; In acetonitrile; at 20 - 80 ℃;

upstream raw materials:

2-bromo-5-fluoro-4-nitroaniline

2,2-dimethyl-3-butynoic acid benzyl ester

Downstream raw materials:

benzyl 2-(6-fluoro-5-nitro- 1H-indol-2-yl)-2-methylpropanoate

Refernces