N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline

Base Information

Chemical Name:N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline
CAS No.:171724-61-1
Molecular Formula:C₃₃H₄₃N₃O₇
Molecular Weight:593.72
Hs Code.:

Synonyms:N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline

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Chemical Property of N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline

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Technology Process of N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline

There total 5 articles about N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 171725-22-7
2-(hept-4-ylcarbonyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}aniline

: 171724-61-1
N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00104-1

Reference yield:

: 2936-08-5
valproyl chloride

: 171724-61-1
N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / Pd(CH₃CN)2Cl₂ / toluene / 0.5 h / 50 °C

2: 78 percent / 30percent aq. HBr, AcOH / 1 h

3: 2.) Et₃N / 2.) DMF, RT, overnight

4: 6 percent / K₂CO₃, KI, nBu₄NBr / dimethylformamide

With dichloro bis(acetonitrile) palladium(II); tetrabutylammomium bromide; hydrogen bromide; potassium carbonate; acetic acid; triethylamine; potassium iodide; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0968-0896(97)00104-1

Reference yield:

: 171725-13-6
N-(N'-Cbz-glycyl)-2-(hept-4-ylcarbonyl)aniline

: 171724-61-1
N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}-2-(hept-4-ylcarbonyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / 30percent aq. HBr, AcOH / 1 h

2: 2.) Et₃N / 2.) DMF, RT, overnight

3: 6 percent / K₂CO₃, KI, nBu₄NBr / dimethylformamide

With tetrabutylammomium bromide; hydrogen bromide; potassium carbonate; acetic acid; triethylamine; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00104-1