ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate
CAS No.:1408186-92-4
Molecular Formula:C₂₀H₂₁Cl₂NO₅S
Molecular Weight:458.362
Hs Code.:

Synonyms:ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

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Chemical Property of ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

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Technology Process of ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

There total 4 articles about ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-31-7
3,4-dichlorobenzenesulphonyl chloride

: C₁₄H₁₉NO₃

: 1408186-92-4
ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 3783-61-7
diethyl 2-azabutane-1,4-dicarboxylate

: 1408186-92-4
ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / chloroform; water / 73 h / 0 - 20 °C

2: potassium tert-butylate / toluene / 1.5 h / -10 - 0 °C / Inert atmosphere

3: calcium chloride; Sucrose / water / 48 h / 30 °C / Microbiological reaction

4: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

6: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; trifluoroacetic acid; calcium chloride; sodium hydroxide; Sucrose; In tetrahydrofuran; dichloromethane; chloroform; water; toluene;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 146256-97-5
3-(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-propionic acid ethyl ester

: 1408186-92-4
ethyl (2R,3S)-3-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / toluene / 1.5 h / -10 - 0 °C / Inert atmosphere

2: calcium chloride; Sucrose / water / 48 h / 30 °C / Microbiological reaction

3: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; trifluoroacetic acid; calcium chloride; Sucrose; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1016/j.ejmech.2012.08.028