(Sp)-8-(2-thienyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoroamidate

Base Information

Chemical Name:(Sp)-8-(2-thienyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoroamidate
CAS No.:872025-92-8
Molecular Formula:C₂₇H₃₅N₆O₅PSSi
Molecular Weight:614.737
Hs Code.:

Synonyms:(Sp)-8-(2-thienyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoroamidate

Suppliers and Price of (Sp)-8-(2-thienyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoroamidate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Sp)-8-(2-thienyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoroamidate

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Technology Process of (Sp)-8-(2-thienyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoroamidate

There total 1 articles about (Sp)-8-(2-thienyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoroamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 872025-83-7
(S_P)-8-bromoadenosine-2'-O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate

: 81745-84-8
2-thienylzinc chloride

: 872025-92-8
(Sp)-8-(2-thienyl)adenosine-2'O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoroamidate

Guidance literature:: (S_P)-8-bromoadenosine-2'-O-(tert-butyldimethylsilyl)-3',5'-cyclic N-benzylphosphoramidate; 2-thienylzinc chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 3h; Heating / reflux;

With water; ammonium chloride; In tetrahydrofuran; dichloromethane; Product distribution / selectivity;