dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate

Base Information

• Chemical Name: dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate
• CAS No.: 1260022-75-0
• Molecular Formula: C₃₇H₆₀NO₆P
• Molecular Weight: 645.86

Synonyms:dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate

Chemical Property of dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate

There total 1 articles about dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-dimethyl 4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-oxo-3-palmitamidobutylphosphonate (1260022-05-6) → dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate (1260022-40-9) + dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate (1260022-75-0)

Guidance literature:

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; In tetrahydrofuran; ethanol; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.09.030

Reference yield: 63.0%

dimethyl (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonate (1260022-75-0) → (3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonic acid (1260023-38-8)

Guidance literature:

With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.09.030

upstream raw materials:

(S)-dimethyl 4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-oxo-3-palmitamidobutylphosphonate

Downstream raw materials:

(3S)-4-(4-(2,4-dimethylbenzyloxy)phenyl)-2-hydroxy-3-palmitamidobutylphosphonic acid

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