ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

Base Information

Chemical Name:ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate
CAS No.:1449278-50-5
Molecular Formula:C₂₃H₂₇FN₂O₄Si
Molecular Weight:442.562
Hs Code.:

Synonyms:ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

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Chemical Property of ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

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Technology Process of ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

There total 6 articles about ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449278-49-2
ethyl 2-chloro-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

: 768-35-4
3-fluorophenylboronic acid

: 1449278-50-5
ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

Guidance literature:: With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; Inert atmosphere;

Reference yield:

: 1449278-46-9
5-bromo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridin-8-one

: 1449278-50-5
ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; N,N-dimethyl-formamide; palladium diacetate; 1,3-bis(dicyclohexylphosphine)propane / 3 h / 85 °C

2.1: urea hydrogen peroxide adduct / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: oxalyl dichloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium phosphate / 1,4-dioxane; water / Inert atmosphere

With potassium phosphate; oxalyl dichloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 1,3-bis(dicyclohexylphosphine)propane; palladium diacetate; urea hydrogen peroxide adduct; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1449278-47-0
ethyl 8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

: 1449278-50-5
ethyl 2-(3-fluorophenyl)-8-oxo-7-(2-trimethylsilylethoxymethyl)-1,7-naphthyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: urea hydrogen peroxide adduct / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium phosphate / 1,4-dioxane; water / Inert atmosphere

With potassium phosphate; oxalyl dichloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); urea hydrogen peroxide adduct; In 1,4-dioxane; dichloromethane; water;